منابع مشابه
Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain.
Pathological aggregation of tau is a hallmark of Alzheimer's disease and related tauopathies. We have previously shown that the deficiency of the microglial fractalkine receptor (CX3CR1) led to the acceleration of tau pathology and memory impairment in an hTau mouse model of tauopathy. Here, we show that microglia drive tau pathology in a cell-autonomous manner. First, tau hyperphosphorylation ...
متن کاملTau Protein: Function and Pathology
1Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical Center, Ein Karem, Jerusalem 91120, Israel 2 Inserm U837, “Alzheimer & Tauopathies” Jean-Pierre Aubert Research Centre, University Lille-Nord de France, UDSL, Lille, France 3Departments of Neurology and Neuroscience & Cell Biology, George and Cynthia Mitchell Center for Neurodegenerativ...
متن کاملInsulin dysfunction and Tau pathology
The neuropathological hallmarks of Alzheimer's disease (AD) include senile plaques of β-amyloid (Aβ) peptides (a cleavage product of the Amyloid Precursor Protein, or APP) and neurofibrillary tangles (NFT) of hyperphosphorylated Tau protein assembled in paired helical filaments (PHF). NFT pathology is important since it correlates with the degree of cognitive impairment in AD. Only a small prop...
متن کاملModulation of tau pathology in tau transgenic models.
NFTs (neurofibrillary tangles) in Alzheimer's disease and in tauopathies are hallmark neuropathological lesions whose relationship with neuronal dysfunction, neuronal death and with other lesions [such as Abeta (amyloid beta-peptide) pathology] are still imperfectly understood. Many transgenic mice overexpressing wild-type or mutant tau proteins have been generated to investigate the physiopath...
متن کاملTransmission of tau pathology induced by synthetic preformed tau filaments.
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ژورنال
عنوان ژورنال: Nature Immunology
سال: 2019
ISSN: 1529-2908,1529-2916
DOI: 10.1038/s41590-019-0572-1